Breakthrough Technology Predicts Shape Changes in DNA Origami Nanostructures

MOLECULAR & COMPUTATIONAL BIOLOGY

8/14/2024

Researchers at Seoul National University's College of Engineering have unveiled a groundbreaking technology that swiftly predicts mechanochemical shape changes in DNA origami nanostructures. DNA origami, which enables the construction of intricate nanometer-scale geometric structures using DNA, garners significant attention for its potential in bio-convergence fields like medical therapy development. However, challenges in modelling and computer simulation have hampered progress. In a July 2024 study published in Nature Communications, the team leveraged molecular dynamics simulations to overcome these hurdles, creating a technology capable of analyzing geometric and mechanical changes in DNA caused by binding molecules. This innovative technology has been validated by its ability to predict shape variations, flexibility modulation, and structural instability in DNA origami due to Ethidium Bromide (EtBr) molecules. With these advancements, the technology promises to elevate DNA origami design and accelerate future progress in DNA nanotechnology and its applications.

Source: https://doi.org/10.1038/s41467-024-50871-3