Researchers Develop CREME, Enabling Thousands of Virtual Genetic Experiments
MOLECULAR & COMPUTATIONAL BIOLOGY
9/26/2024
Cold Spring Harbor Laboratory (CSHL) researchers have successfully developed an AI-based virtual laboratory called cis-regulatory element model explanations (CREME), enabling scientists to conduct thousands of genetic experiments virtually. This study was published in Nature Genetics in September 2024. CREME utilizes models from CRISPR interference (CRISPRi) techniques and sequence-based deep neural networks (DNN), allowing for the large-scale interpretation of gene activity changes in a virtual setting, something that is difficult to achieve in physical laboratories. CREME enables researchers to understand gene regulation more efficiently, potentially aiding in the development of new therapeutic treatments.
