Stanford Researchers Develop New Method to Correct Protein Misplacement within Cells
MOLECULAR & COMPUTATIONAL BIOLOGY
9/27/2024
Researchers at Stanford University have successfully developed a new method to correct the misplacement of proteins within cells, which is a contributing factor to neurodegenerative diseases and cancer. In their study published in Nature in September 2024, the researchers identified a collection of crucial molecules called targeted relocalization activating molecules (TRAMs). By integrating with transport proteins, these molecules can be used to reposition proteins back to their correct locations within the cell. The study also demonstrated that TRAMs can not only restore mislocated endogenous proteins to their rightful positions but can also be utilized to relocate proteins to other desired locations. These findings lay the groundwork for developing new therapies to "treat" diseases resulting from protein misplacement within cells and present a potential tool for deeper exploration of cellular functions.
